REVISTA ELETRÔNICA EXTENSÃO EM DEBATE

O PAPEL DA IL-10 E SEU -819 C>T (rs1800871) NO DESENVOLVIMENTO DAS DOENÇAS PSIQUIÁTRICAS

UMA REVISÃO SISTEMÁTICA DA LITERATURA

Leticia Henrique Leite Silva

Universidade Federal de Alagoas

https://orcid.org/0000-0001-6483-1290

Pedro Bezerra de Oliveira Neto

Universidade Federal de Alagoas

Bruna Brandão dos Santos

Universidade Federal de Alagoas

Jammily de Oliveira Vieira Moreira

Universidade Federal de Alagoas

Renise Bastos Farias Dias

Universidade Federal de Alagoas

Elaine Virgínia Martins de Souza Figueiredo

Universidade Federal de Alagoas

DOI: https://doi.org/10.28998/rexd.v14.15396

Palavras-chave: Interleukin-10. Cytokines. Psychiatric disorders. Psychiatric disease.

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Resumo

A Interleucina 10 (IL-10) é uma citocina pleiotrópica que tem como principal função o controle das respostas imunes. O polimorfismo -819 C>T (rs1800871) no gene IL-10, tem sido associado ao desenvolvimento de comorbidades psiquiátricas. O objetivo deste trabalho foi realizar uma revisão sobre o papel da IL-10 e seu SNP rs1800871 no desenvolvimento de doenças psiquiátricas. Após aplicar os critérios de inclusão e exclusão, foi realizada a leitura completa, totalizando em 36 artigos incluídos. Dessa forma, foi possível observar o predomínio de níveis mais altos de IL-10 associados a diversas doenças psiquiátricas. Quanto ao polimorfismo no gene IL-10, um estudo brasileiro mostrou associação de maior risco de suicídio com pior qualidade de vida ambientalmente e socialmente, levando ao maior risco de suicídio. Além disso, outros estudos mostraram a associação do genótipo C/C e alelo A com a esquizofrenia e do alelo C com a agressividade, assim como o genótipo C/T com efeito protetor para a esquizofrenia. Entretanto, observa-se que há poucos estudos realizados e poucas informações a respeito, sendo necessária a realização de mais pesquisas nessa área. 

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